Clinical Insights & Resources | Nalu Medical
Clinical Insights & Resources
Clinical Evidence Spotlight
New Release
This article, published in Pain Medicine News, highlights real-world evidence demonstrating the effectiveness, safety, and durability of the Nalu Therapy System for chronic neuropathic pain. It also includes a compelling case study of a patient who trialed multiple neuromodulation devices before ultimately finding meaningful, lasting relief with Nalu.
Long-Term Pain Relief Delivered by Micro-Implantable Pulse Generator: Findings from a Large-Scale, Real-World Data Peripheral Nerve Stimulation Patient Registry
John Hatheway, et al.
Published: 2025
Long-Term Clinical Outcomes (24 Months) of Peripheral Nerve Stimulation in the Treatment of Chronic Pain – COMFORT RCT
Mitchell Engle, et al.
Published: 2026
A Confirmatory RCT Evaluating a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain 3- and 6-Month Results from the COMFORT 2 Study
Mitchell Engle, et al.
Published: 2025
Real-World Healthcare Utilization and Costs of Peripheral Nerve Stimulation with a micro-IPG System
Hemant Kalia, et al.
Published: 2024
Safety and Effectiveness of Intraoperative Neuromonitoring in Peripheral Nerve Stimulation: A Single-Center Real-World Data Analysis and Review
Ioannis M Skaribas, et al.
Published: 2025
Articles
The Nalu micro-IPG: Advancing Neurostimulation for the Management of Chronic Neuropathic Pain
Authors: Dr. Timothy R. Deer and Dr. Vinita Singh
Published: Pain Medicine News, December 2025
Peer Reviewed Publications
Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain: 12-Month Results from the COMFORT-Randomized Controlled Trial
John Hatheway, et al.
Published: 2024
John Hatheway, et al.
Published: 2025
Modeling the Impact of the Variation in Peripheral Nerve Anatomy on Stimulation
Lakshmi Narayan Mishra, et al.
Published: 2022
Long-Term Clinical Outcomes (24 Months) of Peripheral Nerve Stimulation in the Treatment of Chronic Pain – COMFORT RCT
Mitchell Engle, et al.
Published: 2026
Design of a Multicenter, Randomized Controlled Trial for the Treatment of Peripheral Neuropathic Pain (COMFORT Study) with a Micro-Implantable Pulse Generator
John Hatheway, et al.
Published: 2024
Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain: 3-Month and 6-Month Results from the COMFORT-Randomised Controlled Trial
John Hatheway, et al.
Published: 2024
Mitchell Engle, et al.
Published: 2025
Real-World Healthcare Utilization and Costs of Peripheral Nerve Stimulation with a micro-IPG System
Hemant Kalia, et al.
Published: 2024
Safety and Effectiveness of Intraoperative Neuromonitoring in Peripheral Nerve Stimulation: A Single-Center Real-World Data Analysis and Review
Ioannis M Skaribas, et al.
Published: 2025
Application of the Novel Nalu Neurostimulation System for Peripheral Nerve Stimulation
Hemant Kalia, et al.
Published: 2022
Posters
Nalu PNS Provides Significant Relief for Refractory Occipital Neuralgia and Cervical Facetogenic Pain
E. Cubillo
Published: 2025
Superior Efficacy of Micro-Implantable Pulse Generator for Chronic Pain Management: COMFORT RCT One-Year Interim Results
M. Engle, et al.
Published: 2025
Functional Outcomes from the COMFORT 2 RCT for Peripheral Nerve Stimulation: Early Results
E. Peskin, et al.
Published: 2025
Pain Outcomes from the COMFORT 2 RCT for Peripheral Nerve Stimulation-Early Results
J. Hatheway, et al.
Published: 2025
Advanced Peripheral Nerve Stimulator Delivers Consistent Pain Relief Across Various Neuropathic Etiologies: COMFORT RCT Findings
J. Hatheway, et al.
Published: 2025
Real World Data Shows Long-Term Pain Relief with Peripheral Nerve Stimulation Delivered from micro-IPG
J. Hatheway, et al.
Published: 2025